Jeffries only joined OTM earlier this year, but has now signed a new long-term agreement with ZPG for both marketing and software services.
Stuart Whiting, Managing Director of The Jeffries Group, said the agency was looking forward to resuming its partnership with Zoopla.
"We are big supporters of the OTM concept, however it simply has not worked for us and does not have the right strategy to succeed in our opinion," Whiting said in a statement.
“We are delighted to be returning to ZPG who have great products for both marketing and software. In addition, we can see a path to having a net revenue relationship with ZPG rather than a cost, with their new MoveIT platform which will generate significant referral fees for us."